Don't stand in front of Zon'ozz if you can help it (to avoid psychic drain).
When Zon'ozz casts Void of the Unmaking we found it best to hug eachother to split the 200,000 damage it does. Direct the Void of the Unmaking towards Zon'ozz so that he'll be hit by it's diffusion and he'll take 5% more damage for every stack of Void Diffusion that the void had on impact. When this happens he will awaken the Mouth of Iso'rath, but lose any stacks of Focused Anger he had acquired.
You can dispell the Disrupting Shadows dot, but it will knock back all players within 10 yards.
Warlord Zon'ozz Spells and Abilities
Focused Anger: Every 5 seconds, Warlord Zon'ozz becomes increasingly focused on his primary target, increasing damage done by 5%.
Psychic Drain: Warlord Zon'ozz channels a wave of psychic force in a cone in front of the himself, dealing 160000 Shadow damage, leeching life for ten times that amount.
Disrupting Shadows: Warlord Zon'ozz curses random targets with Disrupting Shadows. Disrupting Shadows deal 36000 Shadow damage every 2 seconds. If removed, it will knock back all players within 10 yards.
Void of the Unmaking: Warlord Zon'ozz summons a void of shadows. This void will travel forward until it encounters a soul to absorb. The void then diffuses, causing 200000 Shadow damage split evenly between nearby units. The force of this diffusion causes the void to richocet in the opposite direction, and the souls it absorbed increases the damage it deals by 200000% per diffusion.
If the Void of the Unmaking collides with the Warlord Zon'ozz, it will cause a distracting shock to him, increasing the damage he takes by 5% for every stack of Void Diffusion that the void had on impact. This collision enrages Warlord Zon'ozz, causing him to awaken the Mouth of Iso'rath, but lose any stacks of Focused Anger he had acquired.
Blood of the Old Gods: Deals 25000 Shadow damage every 200 second to all nearby enemies.
ADS:
Claw of Iso'rath: These units will knock back nearby players and emit the Blood of the Old Gods (see spell detail above).
Eye of Iso'rath: These units will cast a Shadowy Gaze at a random enemy, dealing 31200 Shadow damage.